A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes belonging to the Schistosoma genus. The mainstay of schistosomiasis control delivery single dose praziquantel (PZQ) through mass drug administration (MDA) programs. These programs have been successful in reducing prevalence and intensity infections. Due success MDA programs, has recently targeted for elimination as public health problem some endemic settings. new World Health Organization (WHO) treatment guidelines aim provide equitable access PZQ individuals above two years old areas. scale up may heighten selection pressures on parasites, which could lead emergence resistant schistosomes. reliance treat this magnitude worrying should resistance develop. Therefore, there need detect track schistosomes counteract threat WHO 2030 NTD roadmap targets. Until recently, studies hindered lack molecular markers associated with resistance. This review discusses recent significant advances understanding basis action S. mansoni proposes additional genetic determinants will also be analyzed context alternative factors that decrease efficacy within field settings, most recommended WHO.